Respiratory syncytial virus immunoprophylaxis in premature infants does not appear to prevent asthma at age 6 years, reported Nienke M. Scheltema, MD, of Wilhelmina Children’s Hospital, Utrecht, the Netherlands, and associates.

In a study of 395 otherwise healthy premature infants who were randomized to receive palivizumab for respiratory syncytial virus (RSV) immunoprophylaxis or placebo and followed for 6 years, 14% of the 199 infants in the RSV prevention group had parent-reported asthma, compared with 24% of the 196 in the placebo group (absolute risk reduction, 9.9%). This was explained mostly by differences in infrequent wheeze, the researchers said. However, physician-diagnosed asthma in the past 12 months was not significantly different between the two groups at 6 years: 10.3% in the RSV prevention group and 9.9% in the placebo group.

In terms of reporting wheeze in the past 12 months, 12% of the 199 children in the RSV prevention group did at the 6-year follow-up, compared with 20% of the 196 in the placebo group (ARR, 8%), while 9% of the RSV prevention group used asthma medication, compared with 13% of the placebo group (ARR, 4%). Lung function results were similar between the two groups.

SOURCE: Scheltema NM et al. Lancet. 2018 Feb 27. doi: 10.1016/S2213-2600(18)30055-9 .


You May Also Like

Portal inflammation in pediatric NAFLD linked to fibrosis

FROM HEPATOLOGY Portal inflammation in children with nonalcoholic fatty liver disease is associated with ...


Urinary tract infections (UTIs) unfortunately present an abundant opportunity for us to reflexively and ...