Respiratory Medicine

  • PCV10 vaccination in Brazil nearly eliminated serotypes

    on May 22nd, 2017
    FROM VACCINE The effect of 10-valent pneumococcal conjugate vaccine (PCV10) after 4 years of routine childhood vaccination in Brazil was near elimination of PCV10 serotypes in a study of over 500 children, said Felipe P.G. Neves, PhD, of the University of California, Berkeley, and his associates. Th[...]
  • GOLD guidelines for the management of COPD – 2017 update

    on May 19th, 2017
    Chronic obstructive lung disease (COPD) is the third leading cause of death in the United States1 and a major cause of mortality and morbidity around the world. The Global Initiative for Chronic Obstructive Lung Disease (GOLD) released a new “2017 Report”2 with modified recommendations for the d[...]
  • Preterm infants at high risk for RSV morbidity without immunoprophylaxis

    on May 18th, 2017
    AT PAS 17 SAN FRANCISCO (FRONTLINE MEDICAL NEWS) – Preterm infants born at 29-35 weeks’ gestation and hospitalized for respiratory syncytial virus (RSV) can experience particularly severe morbidity if they have not received immunoprophylaxis, according to new industry-funded research. Across two[...]
  • Mepolizumab proves effective for eosinophilic granulomatosis with polyangiitis

    on May 17th, 2017
    FROM NEW ENGLAND JOURNAL OF MEDICINE Adding mepolizumab to standard-of-care glucocorticoids with or without immunosuppressive agents can induce remission in many patients who have eosinophilic granulomatosis with polyangiitis (EGPA), according to a report published online May 18 in the New England J[...]
  • Asthma step-up therapy in children improves outcomes

    on May 16th, 2017
    AT PAS 2017 SAN FRANCISCO (FRONTLINE MEDICAL NEWS) – Stepping up pharmacotherapy in children with poorly controlled asthma resulted in fewer asthma-related emergency department (ED) visits and inpatient stays than maintaining current medication therapy, a study found. Perhaps surprisingly, however[...]
  • Women less likely to be diagnosed with sleep disorders

    on May 16th, 2017
    FROM SLEEP MEDICINE Women are less likely to be diagnosed with and treated for sleep disordered breathing (SDB), despite symptoms similar to those of men, according to a study out of Uppsala University. In a survey of 10,854 subjects, 14% of women reported being diagnosed with obstructive sleep apne[...]
  • Tools measuring oxygen desaturation produced disparate data

    on May 16th, 2017
    FROM JOURNAL OF CLINICAL SLEEP MEDICINE WASHINGTON (FRONTLINE MEDICAL NEWS) – Oxygen desaturation index (ODI) scores showed significant variation across two software systems, a study showed. In 106 patients, a comparison of ODI scores assessed using the ResMed ApneaLink Plus system (AL) and the Co[...]
  • Consider invasive mediastinal staging in higher risk NSCLC patients, despite guidelines

    on May 15th, 2017
    FROM THE JOURNAL OF THORACIC AND CARDIOVASCULAR SURGERY Endobronchial ultrasound transbronchial needle aspiration (EBUS-TBNA) appears to be cost effective for use in non–small cell lung cancer (NSCLC) staging if the prevalence of mediastinal lymph node metastasis (MLNM) is greater than or equal to[...]
  • Mycobacteria subset plagues pulmonary patients

    on May 15th, 2017
    FROM CHEST Nontuberculous mycobacteria accounts for an increasing percentage of pulmonary disease, and nonsurgical treatment alone has not shown effectiveness, according to data from a meta-analysis of 24 studies and 1,224 patients. The study results were published online in Chest. Data on therapeut[...]
  • Children’s asthma risk reduced with prenatal vitamin D supplementation

    on May 12th, 2017
    AT PAS 17 SAN FRANCISCO (FRONTLINE MEDICAL NEWS) – Vitamin D supplementation during pregnancy may reduce the incidence of asthma or allergies in children at high risk for atopic disease, a study showed. At age 3 years, asthma or recurrent wheeze occurred in 24% of children born to mothers with sub[...]
  • Atezolizumab improves OS in NSCLC with brain metastases

    on May 12th, 2017
    FROM ELCC GENEVA (FRONTLINE MEDICAL NEWS) – Immune checkpoint inhibitors may improve survival in patients with non–small cell lung cancer (NSCLC) and brain metastases compared with chemotherapy, without adding unacceptable toxicities, pooled analyses of clinical trials suggest. Among 1452 patien[...]
  • FDA: Fluoroquinolone use not linked to retina detachment, aortic problems

    on May 11th, 2017
    The Food and Drug Administration has found no evidence of a link between fluoroquinolone usage and retinal detachment or aortic aneurysm and dissection, according to a new Drug Safety Communication update on potential serious, disabling side effects of oral and injectable fluoroquinolone antibiotics[...]
  • Second generation ALK inhibitors show good response in second-line NSCLC

    on May 11th, 2017
    FROM ELCC GENEVA (FRONTLINE MEDICAL NEWS) – Second-generation inhibitors of the anaplastic lymphoma kinase (ALK) are associated with high response rates in patients with non–small cell lung cancer (NSCLC) who have disease progression after treatment with the first-generation ALK inhibitor crizot[...]
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