ZM-017: Circulating tumor cell assay platform for dogs
As previously disclosed, Zomedica has partnered with Celsee, Inc. (“Celsee”) to develop Celsee’s circulating tumor cell, or CTC, assay, also known as a “liquid biopsy” for use by veterinarians as a cancer diagnostic. The liquid biopsy is a blood test that we believe has the potential to detect the presence of CTCs, which are cells that have shed from a primary tumor into neighboring blood vessels and are transported throughout the body’s circulatory system. We are focusing our development work on testing for difficult to biopsy cancers such as hemangiosarcoma and osteosarcoma in canines. If our development work is successful, we believe this liquid biopsy test will enable veterinarians to detect these hard-to-diagnose cancers with a simple blood draw. In line with the Company’s previously disclosed estimates, clinical validation of ZM-017 began during the first half of 2018. Assuming the successful conclusion of the clinical validation, we continue to expect to commence the marketing of ZM-017 during the second half of 2018.
As previously announced, Zomedica has partnered with Seraph Biosciences, Inc. (“Seraph”) to develop Seraph’s in-clinic diagnostic analyzer for use in the detection of pathogens in companion animals. Our development work is focusing on the use of Seraph’s technology for comprehensive fecal and urine analysis. Detection of fecal parasites, urine bacteria (“urinary tract infection” or “UTI”) and crystals is time-consuming, error-prone and often requires additional outside testing for comprehensive evaluation. If our development work is successful, we believe our analyzer will be able to perform these analyses in seconds, without the need for centrifugation or the use of reagents. The Company is also developing the ability to detect leptospirosis in the urine of infected animals. Leptospirosis is a potentially life-threatening zoonotic disease. Current diagnostic solutions are limited by interference with vaccination and can take days for a confirmatory diagnosis. If our development work is successful, we believe our analyzer will be able to overcome these limitations.
The company expects to begin marketing of ZM-020 in the second half of 2018.
In the longer term, Zomedica also intends to develop additional applications for this technology, including further development of the pathogen detection library for urine and fecal analysis, as well as for respiratory and dermatological analysis. Targeted pathogens may include bacteria, antibiotic resistant bacteria, viruses and fungi.
ZM-011: Transdermal fluoxetine for feline behavioral disorders
ZM-011 is a transdermal formulation of fluoxetine, most commonly known as Prozac®, which is intended to treat behavioral disorders in cats (e.g., inappropriate urination). Consistent with the Company’s earlier guidance, the Company expects to complete pilot testing of ZM-011 in the second half of 2018.
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Investor Relations Contacts
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PCG Advisory Group
Kirin Smith, COO