TEL AVIV, Israel, May 03, 2016 (GLOBE NEWSWIRE) — VBL Therapeutics (Nasdaq:VBLT), a clinical-stage biotechnology company focused on the discovery, development and commercialization of first-in-class treatments for cancer, today announced that data from two Phase 2 clinical studies of VB-111 will be presented at the 2016 American Society of Clinical Oncology (ASCO) Annual Meeting, which will take place June 3 to June 7, 2016 in Chicago.
The ASCO presentation details are as follows:
| Title: Ofranogene obadenovec (VB-111), an anti-cancer gene therapy in combination with bevacizumab to improve overall survival compared to bevacizumab monotherapy in patients with rGBM: A phase 2 historically controlled trial. | ||||||||||||||||||||||||
| Abstract: #2074 | ||||||||||||||||||||||||
| Session Type: Poster Session | ||||||||||||||||||||||||
| Session Title: Central Nervous System Tumors | ||||||||||||||||||||||||
| Date: Saturday, June 4, 2016 | ||||||||||||||||||||||||
| Time: 1:00 PM – 4:30 PM | ||||||||||||||||||||||||
| Location: Hall A | ||||||||||||||||||||||||
| Poster Board: # 261 | ||||||||||||||||||||||||
| Presenter: Andrew Jacob Brenner, MD, PhD, The University of Texas Health Science Center at San Antonio | ||||||||||||||||||||||||
| Title: Tumor responses and preliminary survival data in a phase 2 trial of ofranergene obadenovec (VB-111) combined with paclitaxel in patients with recurrent platinum resistant ovarian cancer. | ||||||||||||||||||||||||
| Abstract: #5551 | ||||||||||||||||||||||||
| Session Type: Poster Session | ||||||||||||||||||||||||
| Session Title: Gynecologic Cancer | ||||||||||||||||||||||||
| Date: Monday, June 6, 2016 | ||||||||||||||||||||||||
| Time: 1:00 PM – 4:30 PM | ||||||||||||||||||||||||
| Location: Hall A | ||||||||||||||||||||||||
| Poster Board: # 374 | ||||||||||||||||||||||||
| Presenter: Richard T. Penson, MD, MRCP, Massachusetts General Hospital | ||||||||||||||||||||||||
Additional data to those included in the abstracts may be included in the presentations.
About VBL Therapeutics
Vascular Biogenics Ltd., operating as VBL Therapeutics, is a clinical stage biopharmaceutical company focused on the discovery, development and commercialization of first-in-class treatments for cancer. The Company’s lead oncology product candidate, VB-111, is a first-in-class, targeted anti-cancer gene-therapy agent that is positioned to treat a wide range of solid tumors. VB-111 is conveniently administered as an IV infusion once every two months. It has been observed to be well-tolerated in >170 cancer patients and we have observed its efficacy signals in an ”all comers“ Phase 1 trial as well as in three tumor-specific Phase 2 studies. The mechanism of VB-111 combines blockade of tumor vasculature with an anti-tumor immune response. This mechanism retains activity regardless of baseline tumor mutations or the identity of the pro-angiogenic factors secreted by the tumor. VB-111 is currently being studied in a Phase 3 pivotal trial for Recurrent Glioblastoma (rGBM). The trial is being conducted under an FDA Special Protocol Assessment (SPA), and VB-111 has obtained fast track and Orphan designations.
Forward Looking Statements:
This press release contains forward-looking statements. All statements other than statements of historical fact are forward-looking statements, which are often indicated by terms such as “anticipate,” “believe,” “could,” “estimate,” “expect,” “goal,” “intend,” “look forward to”, “may,” “plan,” “potential,” “predict,” “project,” “should,” “will,” “would” and similar expressions. These forward-looking statements include, but are not limited to, statements regarding the clinical development of VB-111 and its therapeutic potential and clinical results, including statements related to the Phase 3 pivotal trial for rGBM. These forward-looking statements are not promises or guarantees and involve substantial risks and uncertainties. Among the factors that could cause actual results to differ materially from those described or projected herein include uncertainties associated generally with research and development, clinical trials and related regulatory reviews and approvals, and the risk that historical clinical trial results may not be predictive of future trial results. A further list and description of these risks, uncertainties and other risks can be found in the Company’s regulatory filings with the U.S. Securities and Exchange Commission. Existing and prospective investors are cautioned not to place undue reliance on these forward-looking statements, which speak only as of the date hereof. VBL Therapeutics undertakes no obligation to update or revise the information contained in this press release, whether as a result of new information, future events or circumstances or otherwise.
CONTACT: INVESTOR CONTACT: Michael Rice LifeSci Advisors, LLC (646) 597-6979
