- OSE-127 significantly decreases inflammation in colon biopsies from patients with inflammatory bowel diseases and enhances regulatory T-lymphocytes, the cells that fight inflammation.
- In patients with active mucosal lesions, the overexpression of interleukin-7 receptor (IL-7R, target of OSE-127), is significantly increased and predictive for non-response to anti-TNFα treatment. Moreover, this non-response is strongly correlated to a mucosal defect in regulatory T-lymphocytes.
NANTES, France, May 07, 2018 (GLOBE NEWSWIRE) -- OSE Immunotherapeutics (ISIN: FR0012127173) (Mnémo:OSE) presented new preclinical data* that further supports the potential of OSE-127 for the treatment of inflammatory bowel diseases, at the annual congress of the American Association of Immunologists (May 4-8, Austin, Texas).
The results from colon biopsies of patients with ulcerative colitis confirm that OSE-127 antibody, IL-7Rα antagonist, significantly decreases the inflammation as measured by a reduced gamma interferon secretion level. In parallel, an increase of the score of regulatory T lymphocytes (transcriptomic signature), the cells that help fighting inflammation, was demonstrated after treatment with OSE-127 antibody.
By specifically targeting IL-7R (predictive for non-response to inflammatory bowel disease treatments) and by enhancing in parallel regulatory T lymphocytes in the mucosa, OSE-127 offers an original clinical profile to be developed in invalidating chronic bowel diseases.
*Interleukin-7 receptor pathway controls human T cell homing to the gut and predicts response to anti-TNFα therapy in patients with inflammatory bowel disease
Lyssia Belarif1,2, Richard Danger1,8, Véronique Daguin1, Sabrina Pengam1,2, Caroline Mary1,2, Vanessa Gauttier1,2, Aneta Kucik4, Virginie Thepenier1,2, Tom MacDonald3, Gilles Blancho1,4, Bernard Vanhove1,2, Nicolas Poirier1,2
1Centre de Recherche en Transplantation et Immunologie (CRTI), Inserm, Université de Nantes, France, 2OSE Immunotherapeutics, Nantes, France, 3Blizard Institute, Bartsand the London School of Medicine and Dentistry, London, UK., 4Institut de Transplantation Urologie Néphrologie (ITUN), CHU Nantes, France
ABOUT OSE Immunotherapeutics
OSE Immunotherapeutics is a biotechnology company focused on the development of innovative immunotherapies for immune activation and regulation in the fields of immuno-oncology and autoimmune diseases. Neoepitopes innovation (Tedopi®) is today in Phase 3 in advanced lung cancers (NSCLC) after checkpoint inhibitors failure (anti PD-1 and anti PD-L1). A global license and collaboration agreement was signed in April 2018 with Boehringer Ingelheim to develop checkpoint inhibitor OSE-172 (anti-SIRPa monoclonal antibody), for the treatment of advanced solid tumors. An option to license was exercised in July 2016 by Janssen Biotech to continue clinical development of FR104 (an anti CD28 mAb) in auto-immune diseases after positive phase 1 results. A 2-step license option was signed in 2016 with Servier Laboratories to develop OSE-127 (monoclonal antibody targeting the CD127 receptor, the alpha chain of the interleukin-7 receptor) to develop the product up to the completion of a phase 2 clinical trial planned in autoimmune bowel disease and Sjogren disease. The company has several scientific and technological platforms: neoepitopes, agonist or antagonist monoclonal antibodies, ideally positioned to fight cancer and autoimmune diseases. Its first-in-class clinical portfolio offers a diversified risk profile.
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