A great volume of HIV and AIDS research enters the medical literature every month. It can be difficult to monitor everything, so here’s a quick look at some notable news items and journal articles published over the past few weeks.

Targeted recruitment of hospitalized populations is a feasible and productive approach for finding and engaging people who live with HIV and who are newly diagnosed or out of routine care, according to a study in HIV Clinical Trials.

A comparative study of term, uncomplicated pregnant women , both HIV-infected and -uninfected, found few differences between groups apart from maternal vascular malperfusion, a lesion that may underlie the development of hypertensive disorders of pregnancy and has been observed at higher rates in some HIV-infected women on antiretroviral therapy.

A recent study highlighted the need to enhance the immunogenicity of the seasonal trivalent inactivated influenza vaccine for the HIV-positive population, potentially through harnessing the innate immunity with an external adjuvant.

Greater attention is needed to build a more comprehensive understanding of the rural HIV epidemic in the United States and Canada, including research efforts, innovative approaches to care delivery, and greater community engagement in prevention and care, a recent study revealed.

Recent U.S. research supports prioritizing in-person partner services for HIV and suggests that in-person partner services for syphilis may not have major public health benefit , according to a study in Sexually Transmitted Diseases.

A multinational study of HIV/TB coinfected children highlighted the importance of early antiretroviral therapy for children with HIV/TB coinfection, and reinforced the need for implementation research to improve pediatric TB management.

Placentas of HIV-infected pregnant women under combined antiretroviral therapy containing zidovudine showed evidence of mitochondrial DNA depletion, increased oxidative stress levels, and apoptosis suggestive of secondary mitochondrial failure, all potential bases of associated adverse perinatal outcomes.

U.S. investigators observed no evidence that reporting depressive symptoms increased the likelihood of all-cause mortality in a large cohort of HIV-infected adults in care, controlling for a range of time-varying factors.

The second-generation maturation inhibitor GSK3532795 maintains potent antiviral activity toward HIV protease inhibitor-resistant clinical isolates, according to a study in JAIDS.

Pregnant adolescents must be a priority for primary HIV prevention services and expanded HIV treatment services among pregnant women to achieve an AIDS-free generation in Zimbabwe and similar high HIV burden countries, a recent study revealed.

rpizzi@frontlinemedcom.com

On Twitter @richpizzi

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