Data Highlights the Potential of the CUE-100 Series to Selectively Deliver IL-2 to Tumor-relevant T cells while Mitigating the Risk Associated with Systemic IL-2 Activation
CAMBRIDGE, Mass., Jan. 16, 2019 (GLOBE NEWSWIRE) — Cue Biopharma, Inc., (NASDAQ: CUE) an innovative immunotherapy company developing a novel, proprietary class of biologics engineered to selectively modulate the human immune system to treat cancer, autoimmune and chronic infectious diseases, announced today a poster presentation featuring pre-clinical data on its lead candidate CUE-101, an Immuno-STAT™ (Selective Targeting and Alteration of T cells) Biologic being developed for the treatment of HPV-associated cancers, at the Keystone Symposia Conference, January 20-24 in Vancouver, British Columbia.
Details for the poster presentation are as follows:
Title: CUE-101, a novel Fc fusion for selective targeting and expansion of anti-tumor T cells for treatment of HPV-driven malignancies
Poster Number: 1035
Poster Session: Poster Session 1, Monday, January 21, 2019
Location: Fairmont Hotel Vancouver
Authors: Saso Cemerski, Steven N. Quayle, Dharma Raj Thapa, Sandrine Hulot, Alyssa Nelson, Lauren Kraemer, Zohra Merazga, Robert Ruidera, Dominic Beal, Gurpanna Saggu, Maria Hackett, Mark Haydock, Jonathan Soriano, Luke Witt, Simon Low, Natasha Girgis, Emily Spaulding, John F. Ross, Anish Suri, Rodolfo Chaparro, Ronald Seidel, Kenneth J. Pienta, Mary C. Simcox
“Cue Biopharma is pleased to present important data highlighting the potential of our Immuno-STAT platform and lead candidate CUE-101 to enhance anti-tumor immunity in patients with HPV16-driven malignancies,” said Anish Suri, Ph.D., Senior Vice President and Chief Scientific Officer of Cue Biopharma. “CUE-101, as representative of our CUE-100 series, demonstrated selective binding, preferential activation and in vitro expansion of antigen-specific T cells – even with transient exposure to the drug. Furthermore, direct effects of CUE-101 versus wild type IL-2 on human primary blood mononuclear cells (PBMCs) demonstrated significant reduction of non-specific cytokine production and cell-surface activation markers. We believe these early data support a potentially favorable safety and efficacy profile for the CUE-100 series that contains affinity attenuated IL-2 to favor tumor-specific T cell engagement over systemic IL-2 that interacts broadly with all T cells and other immune cells.”
“The data to be presented demonstrates our ability to protein engineer a selective T cell modulatory biologic providing the benefits of selective IL-2 activity while eliminating or ameliorating the unwanted collateral effects of non-selective, global stimulators,” said Dan Passeri, M.Sc., J.D., President and CEO of Cue Biopharma. “Through protein engineering, we have developed an IL-2 framework forming the basis of our CUE-100 series, which holds tremendous promise for addressing a myriad of cancers by changing the targeting epitope, such as HPV for CUE-101 and WT1 for CUE-102.”
The poster also shows that in this study, CUE-101 induced inhibition of tumor growth in vivo both as a monotherapy, and in combination with a PD-1 inhibitor.
The poster will be available in the Events and Presentations section of the Investor page at www.cuebio.com following the presentation at the Keystone Symposia Conference.
Cue Biopharma previously presented foundational data on CUE-101 and the Immuno-STAT platform at the Society for Immunotherapy of Cancer’s (SITC) 33rd Annual Meeting in November.
About CUE-100 Framework
Drug candidates developed within the CUE-100 framework selectively stimulate the interleukin 2 (IL-2) receptor, a potent activator of the pathway critical to the growth, expansion and survival of T cells. We have engineered the framework to activate specific T cell populations through peptide-MHC complex (pMHC) targeting of T cell receptors (TCRs) and selective deployment of the IL-2 signal. The IL-2 has been attenuated to achieve preferential activation of tumor specific T-cells without systemic activation, potentially mitigating the dose-limiting toxicities associated with current IL-2-based therapies.
The lead program from the CUE-100 framework, CUE-101, contains IL-2 and a pMHC composed of HLA-A*02:01 complexed with a dominant peptide derived from the human papilloma virus E7 protein (HPV-E7). It is a fusion protein biologic designed to target and activate antigen-specific T cells to fight HPV-driven cancers.
Immuno-STAT Biologics are designed for targeted modulation of disease-associated T cells in the areas of immuno-oncology, autoimmune and chronic infectious disease. Each of our biologic drugs is designed using our proprietary scaffold comprising: 1) a peptide-MHC complex (pMHC) to provide selectivity through the pMHC T-cell receptor (TCR) interaction, and 2) a unique co-stimulatory signaling molecule to modulate the activity of the target T cells.
The simultaneous engagement of co-stimulatory molecules and pMHC binding mimics the signals delivered by antigen presenting cells (APCs) to T cells during a natural immune response. This design enables Immuno-STAT Biologics to engage with the T cell population of interest exclusively, resulting in highly targeted T cell modulation. Because our drugs are delivered in vivo, they are fundamentally different from other T cell therapeutic approaches such as Adoptive Cell Therapy (ACT), which require the patients’ T cells to be extracted, then stimulated and expanded outside the body (ex vivo) and reinfused in an activated state. At Cue Biopharma, we are working to develop drugs that will represent a potent pharmaceutical analog to the ex vivo approach deployed by current cellular therapies. Furthermore, we believe the pharmacological effect in the patients can be more precisely controlled via an administered therapeutic.
About Cue Biopharma
Cue Biopharma is an innovative immunotherapy company developing a novel, proprietary class of biologics engineered to selectively modulate the human immune system to treat a broad range of cancers, autoimmune and chronic infectious diseases. We design biologics to engage and modulate the activity of disease-associated T cells in the patient’s body, with the goal of offering significant therapeutic benefits while potentially minimizing or eliminating unwanted side effects.
We believe our selective biologics allow us to target antigen-specific T cell populations in a variety of indications using a peptide – MHC complex for delivering T cell modulating effectors, such as IL-2. Once a biologic has been optimized, our approach offers the potential for readily exchanging peptides to target different T cell populations and indications using previously-validated drug frameworks developed from the Immuno-STATTM (Selective Targeting and Alteration of T cells) platform. This flexibility could truncate the drug selection and development process, moving effective therapeutics from discovery to clinical validation more rapidly and cost-efficiently than current industry standard timelines and costs.
Headquartered in Cambridge, MA, we are led by an experienced management team and scientific and clinical advisory board (SAB/CAB) with deep expertise in the design and clinical development of protein biologics, immunology and immuno-oncology.
For more information, visit www.cuebio.com.
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