Oncology

  • Fewer post-transplant CMV infections with novel antiviral prophylaxis

    on February 24th, 2017
    AT THE 2017 BMT TANDEM MEETINGS ORLANDO (FRONTLINE MEDICAL NEWS) – A first-in-class antiviral drug was safe and effective when used to prevent clinically significant cytomegalovirus infections in adults undergoing hematopoietic cell transplantation. At 24 weeks post-transplant, 38% (122/325) of th[...]
  • For mantle cell lymphoma, VR-CAP beat R-CHOP

    on February 24th, 2017
    FROM HAEMATOLOGICA For patients with newly diagnosed mantle cell lymphoma, duration and quality of response were superior with a regimen of bortezomib, rituximab, cyclophosphamide, doxorubicin, and prednisone (VR-CAP) when compared with rituximab, cyclophosphamide, doxorubicin, vincristine, and pred[...]
  • New significantly mutated genes detected in prostate cancer

    on February 23rd, 2017
    FROM THE GENITOURINARY CANCERS SYMPOSIUM A new large study has identified 78 significantly mutated genes (SMGs) and has enlarged the genetic landscape of prostate cancer. In addition, 37 genes that were not previously reported as SMGs in prostate cancer and 23 that were not previously identified as [...]
  • Single BEP adjuvant chemotherapy cycle ‘sufficient’ in testicular cancer

    on February 23rd, 2017
    AT THE GENITOURINARY CANCERS SYMPOSIUM ORLANDO (FRONTLINE MEDICAL NEWS) – Although two cycles of bleomycin-etoposide-cisplatin (BEP) chemotherapy typically comprise adjuvant treatment for nonseminomatous or combined germ cell testicular cancer, investigators suggest one cycle may be sufficient. [...]
  • Chemoradiation standard of care in muscle-invasive bladder cancer

    on February 23rd, 2017
    AT THE GENITOURINARY CANCERS SYMPOSIUM Orlando (FRONTLINE MEDICAL NEWS) – The updated results of a large phase III trial support the use of chemoradiation with 5-fluorouracil (5-FU) and mitomycin C (MMC) and confirm that this treatment regimen should be a standard of care for muscle-invasive bladd[...]
  • Personal finances affect cancer survivors’ medication use

    on February 22nd, 2017
    FROM CANCER Adult cancer survivors under the age of 65 are more likely to alter their use of prescription drugs for financial reasons than are those without a history of cancer, according to a report published online Feb. 20. Among nonelderly adults, 31.6% of those who had been diagnosed within the [...]
  • Watch and wait often better than resecting in ground-glass opacities

    on February 22nd, 2017
    FROM CHEST Three years of follow-up is adequate for partially solid ground-glass opacity lesions that do not progress, while pure ground-glass opacity lesions that show no progression may require further follow-up care, a study suggests. The results of the long-term outcome investigation of 226 pati[...]
  • Hormone therapy prolongs PFS in rare low-grade serous cancer

    on February 21st, 2017
    FROM THE JOURNAL OF CLINICAL ONCOLOGY Hormone maintenance therapy, when given after primary cytoreductive surgery and platinum-based chemotherapy, prolonged progression-free survival among women who had low-grade serous carcinoma of the ovary or peritoneum, a study showed. Low-grade serous carcinoma[...]
  • Osimertinib helps NSCLC that progresses despite EGFR-TKIs

    on February 21st, 2017
    FROM THE JOURNAL OF CLINICAL ONCOLOGY Osimertinib, an epidermal growth factor receptor tyrosine kinase inhibitor selective for both EGFR and T790M mutations that render cancers resistant to EGFR-TKIs, yielded a high overall response rate, “encouraging” progression-free survival, and a durable tr[...]
  • One-third of micropapillary thyroid cancer found to be multifocal

    on February 21st, 2017
    AT THE ACADEMIC SURGICAL CONGRESS LAS VEGAS (FRONTLINE MEDICAL NEWS) – Micropapillary thyroid carcinoma may not be as indolent as generally thought, according to the findings of a retrospective study of thyroidectomy cases. A review of 213 patients diagnosed with the cancer found that 34% of them [...]
  • Oral contraceptive use confers long-term cancer protection

    on February 21st, 2017
    FROM THE AMERICAN JOURNAL OF OBSTETRICS AND GYNECOLOGY New findings from a cohort study with more than 4 decades of follow-up show that, while women who have ever used combined oral contraceptives see an increased risk of breast and cervical cancer, the risk disappears within about 5 years after sto[...]
  • No AR in CTCs linked with better survival in advanced prostate cancer

    on February 17th, 2017
    FROM THE GENITOURINARY CANCERS SYMPOSIUM The presence and amount of full-length androgen receptor biomarker detected in the circulating tumor cells of people with metastatic castration-resistant prostate cancer can inform prognosis, a prospective study reveals. Investigators report significant diffe[...]
  • Can a nomogram foretell invasive pulmonary adenocarcinoma?

    on February 17th, 2017
    EXPERT ANALYSIS FROM THE JOURNAL OF THORACIC AND CARDIOVASCULAR SURGERY The diagnosis of solitary peripheral subsolid nodule carries with it an undefined risk of invasive pulmonary carcinoma, but clinicians have not had a tool that can help guide their planning for surgery. However, researchers in C[...]
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