Nephrology and Urology

  • New significantly mutated genes detected in prostate cancer

    on February 23rd, 2017
    FROM THE GENITOURINARY CANCERS SYMPOSIUM A new large study has identified 78 significantly mutated genes (SMGs) and has enlarged the genetic landscape of prostate cancer. In addition, 37 genes that were not previously reported as SMGs in prostate cancer and 23 that were not previously identified as [...]
  • Three signs predict hypercalcemic crisis in hyperparathyroid patients

    on February 22nd, 2017
    AT THE ACADEMIC SURGICAL CONGRESS LAS VEGAS (FRONTLINE MEDICAL NEWS) – A triad of signs – elevated serum calcium, elevated parathyroid hormone, and a history of kidney stones – can predict hypercalcemic crisis among patients with hyperparathyroidism, a study showed. Patients who present with t[...]
  • No AR in CTCs linked with better survival in advanced prostate cancer

    on February 17th, 2017
    FROM THE GENITOURINARY CANCERS SYMPOSIUM The presence and amount of full-length androgen receptor biomarker detected in the circulating tumor cells of people with metastatic castration-resistant prostate cancer can inform prognosis, a prospective study reveals. Investigators report significant diffe[...]
  • Survival gains with pembrolizumab in urothelial cancer

    on February 17th, 2017
    FROM THE GENITOURINARY CANCERS SYMPOSIUM Treatment with checkpoint inhibitor pembrolizumab is associated with significant gains in overall survival among patients with treatment-refractory advanced urothelial carcinoma, according to new research. Data from the KEYNOTE-045 trial was presented simulta[...]
  • RNA-based biopsy test bests NCCN risk stratification for PC prognosis

    on February 17th, 2017
    AT THE GENITOURINARY CANCERS SYMPOSIUM ORLANDO (FRONTLINE MEDICAL NEWS) – A genetic assay for prostate cancer typically used after radical prostatectomy could be used earlier, at the time of diagnostic biopsy testing, to classify patients as low, intermediate, and high risk for metastasis and dise[...]
  • Clinical benefit persists for some with mRCC after stopping immune checkpoint blockade

    on February 15th, 2017
    FROM THE 2017 GENITOURINARY CANCERS SYMPOSIUM ORLANDO (FRONTLINE MEDICAL NEWS) – Some people with advanced kidney cancer who respond to immune checkpoint inhibitor therapy and subsequently stop because of immune-related adverse events may continue to see a clinical benefit for 6 months or longer, [...]
  • Antibiotic use may hamper checkpoint inhibitors for mRCC

    on February 14th, 2017
    FROM THE GENITOURINARY CANCERS SYMPOSIUM Antibiotics may hamper the effectiveness of immune checkpoint inhibitors for patients with metastatic renal cell carcinoma, according to a small, retrospective study. Using antibiotics within 1 month of starting a checkpoint inhibitor was associated with sign[...]
  • Circulating tumor DNA could guide therapy for advanced prostate cancer

    on February 14th, 2017
    FROM THE GENITOURINARY CANCERS SYMPOSIUM ORLANDO – New research indicates that genetic changes over time in circulating cell-free tumor DNA of patients with advanced prostate cancer could help clinicians detect emerging treatment resistance and adjust treatment regimens accordingly. Also, specific[...]
  • Medical organizations respond to Trump’s immigration order

    on February 1st, 2017
    Organizations representing physicians and medical students have expressed their concern regarding President Trump’s executive order of Jan. 27 that curtails entry into the United States by travelers from seven Muslim-majority countries. The order also suspends for 120 days entry into the United St[...]
  • Antiandrogen therapy improves survival after biochemical recurrence of prostate cancer

    on February 1st, 2017
    FROM THE NEW ENGLAND JOURNAL OF MEDICINE Adding antiandrogen treatment to salvage radiotherapy markedly improves long-term survival and disease-specific mortality, reduces the rate of distant metastases, and decreases the incidence of further recurrences in men who have an initial biochemical recurr[...]
  • An alternative device for ESRD patients with central venous obstruction

    on January 25th, 2017
    AT THE NORTHWESTERN VASCULAR SYMPOSIUM CHICAGO (FRONTLINE MEDICAL NEWS) – Catheter dependence is often the final option available for hemodialysis patients who have exhausted upper extremity access because of central venous obstruction. But an alternative device that combines a standard expanded p[...]
  • Serum magnesium level reflects risk of death, irrespective of CKD

    on January 22nd, 2017
    AT THE ANNUAL MEETING OF THE AMERICAN SOCIETY FOR NEPHROLOGY CHICAGO (FRONTLINE MEDICAL NEWS) – Low levels of serum magnesium were associated with increased all-cause mortality, whether or not patients had chronic kidney disease, in a single center, retrospective study of 3,551 people. The associa[...]
  • Constipation severity linked with chronic kidney disease and decline in kidney function

    on January 22nd, 2017
    AT THE ANNUAL MEETING OF THE AMERICAN SOCIETY FOR NEPHROLOGY CHICAGO (FRONTLINE MEDICAL NEWS) – Constipation was associated with poor kidney health in a large nationwide cohort of 3.5 million United States veterans, and researchers are considering whether effectively treating constipation could he[...]
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