Infectious diseases

  • HCV pregnancy increase suggests need for broader screening

    on May 11th, 2017
    FROM MMWR Hepatitis C virus (HCV) infection among women giving birth increased 89% from 1.8 cases per 1,000 live births in 2009 to 3.4 cases in 2014, translating to about 35 infants exposed to the virus per day in the United States in 2014, according to the May 11 Morbidity and Mortality Weekly Repo[...]
  • For vertebral osteomyelitis, early switch to oral antibiotics is feasible

    on May 11th, 2017
    AT ECCMID 2017 VIENNA (FRONTLINE MEDICAL NEWS) – A 6-week course of antibiotics, with an early switch from intravenous to oral, appears to be a safe and appropriate option for some patients with pyogenic vertebral osteomyelitis. A single-center retrospective study of 82 such patients found two tre[...]
  • Ribaxamase prevented C. difficile infections by protecting microbiome

    on May 11th, 2017
    AT ECCMID 2017 VIENNA (FRONTLINE MEDICAL NEWS) – An investigational beta-lactamase reduced Clostridium difficile infections by 71% in patients receiving extended antibiotic therapy for respiratory infections but not by killing the opportunistic bacteria. Rather, ribaxamase prevented C. difficile i[...]
  • Topical imiquimod boosted response to intradermal hepatitis B vaccine

    on May 11th, 2017
    AT ECCMID 2017 VIENNA (FRONTLINE MEDICAL NEWS) – Topical imiquimod appeared to enhance the immunogenicity of an intradermal hepatitis B vaccine in patients on renal replacement therapy. Patients on hemodialysis or peritoneal dialysis who got the combination developed significantly higher seroprote[...]
  • Survival in the first 3 years of ART continues to improve

    on May 11th, 2017
    FROM THE LANCET HIV Mortality continues to decline for patients in the first 3 years of combination antiretroviral therapy (ART) for HIV-1 infection, according to an analysis of 18 different cohorts from 1996 to 2013. The Antiretroviral Therapy Cohort Collaboration (ART-CC) combined data from partic[...]
  • Safe, effective backup for U.S. MMR vaccine exists

    on May 10th, 2017
    FROM HUMAN VACCINES & IMMUNOTHERAPEUTICS Antibodies against measles, mumps, and rubella persisted for up to 2 years after vaccination of children 12-15 months with the MMR vaccine approved in the United States and a similar one approved in Europe, both of which are manufactured without human ser[...]
  • Time to therapy for gram-positive bacteremia reduced from 60 hours to 4 hours

    on May 10th, 2017
    AT PAS 2017 SAN FRANCISCO (FRONTLINE MEDICAL NEWS) – Implementation of sample testing using a molecular approach, combined with coordinated and multidisciplinary notification of clinicians, has reduced the time to deliver adequate antibiotic therapy for bacteremia caused by gram-positive cocci inc[...]
  • Adult vaccination is low, with minimal improvement in recent years

    on May 10th, 2017
    FROM MMWR Only minimal improvements have been made in vaccination coverage among U.S. adults in recent years, reported Walter W. Williams, MD, of the National Center for Immunization and Respiratory Diseases, Atlanta, and his associates. In an analysis of data from the 2015 National Health Interview[...]
  • Lower-dose aluminum hydroxide–adjuvanted polio vaccine noninferior to standard IPV

    on May 9th, 2017
    FROM THE LANCET INFECTIOUS DISEASES Aluminum hydroxide–adjuvanted vaccines with reduced doses of inactivated polio vaccine (IPV-Al) were noninferior to standard inactivated poliovirus vaccine (IPV) in a large trial in the Dominican Republic, said Luis Rivera, MD, of the Hospital Maternidad Nuestra[...]
  • Consider strongyloidiasis before giving oral steroids

    on May 9th, 2017
    EXPERT ANALYSIS AT ACDASM 2017 SYDNEY (FRONTLINE MEDICAL NEWS) – Think twice before prescribing oral steroids for patients who have urticarial dermatitis, diarrhea, and cough, especially if they have lived in or recently traveled to tropical areas, Ian McCrossin, MD, said at the annual meeting of [...]
  • Dalbavancin proves highly effective in osteomyelitis

    on May 9th, 2017
    AT ECCMID 2017 VIENNA (FRONTLINE MEDICAL NEWS) – Two infusions of the long-acting lipoglycopeptide antibiotic dalbavancin showed a favorable clinical benefit for treatment of adult osteomyelitis in a phase II study. Dalbavancin (Dalvance) showed positive results while avoiding the complexities of [...]
  • UTI predictors identified in infants under 3 months of age

    on May 9th, 2017
    AT PAS 17 SAN FRANCISCO (FRONTLINE MEDICAL NEWS) – Serum leukocytosis, pyuria, and urine leukocyte esterase have been identified as predictors of urinary tract infection (UTI) in infants younger than 90 days of age, with males being more likely to develop UTI than females. Fever and gestational ag[...]
  • Constipation implicated as an indicator of Helicobacter pylori infection

    on May 8th, 2017
    AT PAS 17 SAN FRANCISCO (FRONTLINE MEDICAL NEWS) – Infants who are constipated should be tested for the presence of Helicobacter pylori infection. Just relying on the detection of antigen to H. pylori in stool may not be a definitive indicator of the bacterial infection; endoscopic biopsy is a mor[...]
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