• Oral, liquid supplement improves clinical outcomes in lactose-intolerant adults

    on January 13th, 2017
    FROM THE PROCEEDINGS OF THE NATIONAL ACADEMIES OF SCIENCE Adults with self-reported lactose intolerance were shown to have significant improvement in their clinical outcomes, including abdominal pain, after consuming an oral, liquid supplement intended to increase lactose-fermenting gut bacteria, M.[...]
  • AGA Clinical Practice Update: CommentEndoscope reprocessing guidelines fall short on preventing outbreaks

    on January 13th, 2017
    FROM GASTROENTEROLOGY While the 2016 Multi-Society Task Force Endoscope Reprocessing Guidelines are an improvement over the 2011 guidelines, some of its minor changes are unlikely to guarantee against prevention of future outbreaks, according to Susan Hutfless, PhD, and Anthony N. Kalloo, MD. “The[...]
  • High consumption of red meat increases diverticulitis risk in men

    on January 13th, 2017
    FROM GUT Men who consume higher quantities of red meat are at an increased risk of developing diverticulitis, especially if they’re eating unprocessed red meat, according to a new study published in Gut. “In our prior analysis from a large prospective cohort study, the Health Professionals Follo[...]
  • 177Lu-Dotatate for advanced midgut neuroendocrine tumors

    on January 12th, 2017
    FROM THE NEW ENGLAND JOURNAL OF MEDICINE 177Lu-Dotatate, a radionuclide related to octreotide, reduced the risk of disease progression or death by 79% in a phase III trial involving 229 adults with advanced, progressive midgut neuroendocrine tumors, investigators reported in the New England Journal [...]
  • Half of newly detected antimicrobial antibodies do not lead to PBC

    on January 10th, 2017
    FROM HEPATOLOGY Nearly half of newly detected antimitochondrial antibodies (AMAs) in clinical practice do not lead to a diagnosis of primary biliary cholangitis (PBC), according to a prospective study. Geraldine Dahlqvist, MD , and her associates examined 720 patients whose AMA tests were registered[...]
  • Medicare payments set for infliximab biosimilar Inflectra

    on January 10th, 2017
    Payment for the infliximab biosimilar drug Inflectra will now be covered by Medicare, the drug’s manufacturer, Pfizer, said in an announcement. The Centers for Medicare & Medicaid Services (CMS) included Inflectra (infliximab-dyyb) in its January 2017 Average Sales Price pricing file , which w[...]
  • Sorafenib survival benefit in HCC depends on etiology

    on January 6th, 2017
    FROM THE JOURNAL OF CLINICAL ONCOLOGY The impact of sorafenib in treating patients with advanced hepatocellular cancer may be dependent on their hepatitis status, according to a meta-analysis of patient-level data from three large prospective clinical trials using sorafenib as the control treatment.[...]
  • Gastric cancer yields to growth hormone antagonist in lab

    on January 6th, 2017
    FROM PNAS It sounds counterintuitive, but targeting a neuropeptide hormone produced in the hypothalamus may be an effective strategy for treating gastric cancer, the second most common cause of cancer deaths worldwide, investigators from China and the United States contend. Growth hormone–releasin[...]
  • Hepatitis outlook: December 2016

    on January 6th, 2017
    If you work on the front lines of medical care treating patients with hepatitis, you may not have time to review all the hepatitis research that enters the medical literature every month. Here’s a quick look at some notable news items and journal articles published over the past month, covering a [...]
  • Meta-analysis compares infliximab with tacrolimus in ulcerative colitis

    on January 4th, 2017
    AT AIBD 2016 ORLANDO – Infliximab and tacrolimus each demonstrate efficacy for treatment of moderate to severe active ulcerative colitis in published studies. However, it remains unknown if one agent offers greater efficacy than the other in this patient population, so researchers in Japan conduct[...]
  • Lysosomal acid lipase replacement corrects genetic cause of liver failure, atherosclerosis

    on January 4th, 2017
    AT THE LIVER MEETING 2016 BOSTON (FRONTLINE MEDICAL NEWS) – Lysosomal acid lipase deficiency (LAL-D), a rare genetic cause of marked dyslipidemia that causes early multisystem organ damage, was effectively treated by a human recombinant enzyme to replace deficient lysosomal acid lipase, and the re[...]
  • Vedolizumab effective at treating UC in wide range of patients

    on January 3rd, 2017
    FROM CLINICAL GASTROENTEROLOGY AND HEPATOLOGY When treating patients for ulcerative colitis (UC), clinicians should consider using vedolizumab, because the drug has been found to be both safe and highly effective in patients who have never received tumor necrosis factor (TNF)–antagonist treatment [...]
  • Endoscopy during pregnancy increases risk of preterm, SGA birth

    on January 3rd, 2017
    Women who undergo an endoscopy during pregnancy are increasing the chances that their baby will be born preterm, or be small for gestational age (SGA), according to research published in the February issue of Gastroenterology (doi: 10.1053/j.gastro.2016.10.016). “Research in pregnancy outcome in w[...]
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