• Biosimilar immunogenicity studies produce no surprises

    on June 25th, 2017
    MADRID (FRONTLINE MEDICAL NEWS) – Two biosimilar tumor necrosis factor inhibitor (TNFi) products are no more immunogenic than their reference biologic counterparts in patients with rheumatoid arthritis (RA), according to the results of two studies presented at the European Congress of Rheumatology[...]
  • Obeticholic acid fails to prevent liver damage in an animal model of short-bowel syndrome

    on June 25th, 2017
    FROM CMGH Obeticholic acid failed to prevent the development of short-bowel syndrome–associated liver disease in a preliminary study using piglet models. The findings were published in the July issue of Cellular and Molecular Gastroenterology and Hepatology ( doi: 10.1016/j.jcmgh.2017.02.008 ). Cu[...]
  • Novel ibuprofen formulation cuts GI side effects in patients with knee pain flares

    on June 23rd, 2017
    AT OARSI 2017 LAS VEGAS (FRONTLINE MEDICAL NEWS) – A novel lipid formulation of ibuprofen given at 1,200 mg/day proved noninferior to high-dose standard ibuprofen at 2,400 mg/day for management of episodic knee pain flares in a phase III randomized trial, and it accomplished this with significantl[...]
  • Liver disease doubles risk of colorectal cancer

    on June 21st, 2017
    FROM GASTROINTESTINAL ENDOSCOPY Chronic liver disease appears to double the risk of colorectal cancer (CRC), even after patients undergo liver transplantation, according to a report published in Gastrointestinal Endoscopy. “Strict surveillance for colorectal cancer is warranted in this patient pop[...]
  • HCV/HIV-coinfected teens rapidly progress to advanced liver disease

    on June 20th, 2017
    AT ESPID 2017 MADRID (FRONTLINE MEDICAL NEWS) – Roughly one in four children with vertically transmitted hepatitis C virus (HCV)/HIV coinfection will progress to advanced hepatic fibrosis by age 20 years despite treatment with pegylated interferon plus ribavirin, Carolina Fernández McPhee, MD, re[...]
  • Massive blood transfusions increase risk with CRS/HIPEC

    on June 20th, 2017
    FROM THE JOURNAL OF GASTROINTESTINAL SURGERY Massive allogenic blood transfusion during cytoreductive surgery with hyperthermic intraperitoneal chemotherapy (CRS/HIPEC) increased the risk of major complications and reduced overall survival in a review of 936 cases at St. George Hospital near Sydney,[...]
  • Sooner is better than later for acute UC surgery

    on June 18th, 2017
    AT ASCRS 2017 SEATTLE (FRONTLINE MEDICAL NEWS) – Postponing surgery for acute ulcerative colitis more than a day increases postoperative complications, lengths of stay, and hospital costs, according to a review by Johns Hopkins University, Baltimore, of almost 2,000 patients. It’s not uncommon t[...]
  • PBC incidence remains stable in rural parts of U.S.

    on June 17th, 2017
    FROM CLINICAL MEDICINE & RESEARCH The incidence of primary biliary cholangitis (PBC) in rural parts of the midwestern United States has remained stable over the last 2 decades, allowing better prognosis and improved survival rates. In a population-based cohort study, Rajan Kanth, MD, and his ass[...]
  • Outpatient appendectomy success depends on patient selection, communication

    on June 13th, 2017
    FROM JOURNAL OF THE AMERICAN COLLEGE OF SURGEONS Outpatient laparoscopic surgery for uncomplicated appendicitis can be safely implemented in a large county hospital that serves a poor, underserved population, findings from a prospective, observational trial have shown. Outpatient appendectomy has gr[...]
  • For chronic abdominal pain, THC resembled placebo

    on June 12th, 2017
    FROM CLINICAL GASTROENTEROLOGY AND HEPATOLOGY Seven weeks of treatment with delta-9-atetrahydrocannabinol (THC) did not improve chronic abdominal pain in a placebo-controlled trial of 65 adults. Treatment “was safe and well tolerated,” but did not significantly reduce pain scores or secondary ef[...]
  • Study supports expanded definition of serrated polyposis syndrome

    on June 12th, 2017
    FROM GASTROENTEROLOGY Patients with more than 10 colonic polyps, of which at least half were serrated, and their first-degree relatives had a risk of colorectal cancer similar to that of patients who met formal diagnostic criteria for serrated polyposis syndrome (SPS), according to a retrospective m[...]
  • Improved adenoma detection rate found protective against interval cancers, death

    on June 12th, 2017
    FROM GASTROENTEROLOGY An improved annual adenoma detection rate was associated with a significantly decreased risk of interval colorectal cancer (ICRC) and subsequent death in a national prospective cohort study published in the July issue of Gastroenterology (doi: 10.1053/j.gastro.2017.04.006). Thi[...]
  • Steatosis linked to persistent ALT increase in hepatitis B

    on June 12th, 2017
    FROM CLINICAL GASTROENTEROLOGY AND HEPATOLOGY About one in five patients with chronic hepatitis B virus (HBV) infection had persistently elevated alanine aminotransferase (ALT) levels despite long-term treatment with tenofovir disoproxil fumarate, according to data from two phase III trials reported[...]
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